Disorder Drives One of Nature’s Most Complex Machines

Every second, hundreds to thousands of molecules move through thousands of nuclear pores in each of your cells. A new high-definition view reveals the machine in action.

At the dawn of complex life, evolution created a container for DNA, its most treasured item. A few billion years later, 20th-century microscopists looked at this container — the nucleus — up close and saw that it was covered in tiny openings. At the time, they didn’t know what to make of these structures, but as microscopy improved, something grand came into focus: what we now call “nuclear pore…

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